Estimated reading time: 4 minutes
GLP-1 medications are a popular option for weight loss. Over the last few years, they have helped thousands of people lose weight by reducing appetite and improving metabolic function. However, one question many people have is: what happens when you stop taking these medications? For one of many reasons, you may decide to stop taking GLP-1s. It could be because of cost, a major life change, or personal preference! Here, PatientsLikeMe will explain how GLP-1 drugs work, what happens when you stop, reasons why people stop using them, and some strategies to keep weight loss after stopping.
What Are GLP-1s and How Do They Help with Weight Loss?
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications originally made for managing type 2 diabetes. They have since been approved for weight loss because of their ability to reduce appetite, slow digestion, and regulate blood sugar levels. Some common examples are:
- Semaglutide (Wegovy, Ozempic)
- Tirzepatide (Mounjaro, Zepbound)
- Liraglutide (Saxenda, Victoza)
- Dulaglutide (Trulicity)
- Exenatide (Bydureon)
These drugs mimic natural gut hormones that tell the brain you are full, making it easier for people to eat less and lose weight. However, their effects are greatly reduced when you stop taking the medication.
What Happens When You Stop Taking Weight Loss Drugs?
When people stop taking GLP-1 medications, the body often goes back to how it previously regulated weight. This can lead to rapid weight regain. Research has shown that within a year of stopping semaglutide, most people regain two-thirds of the weight they lost while on the drug. This is because of:
- Increased hunger and food cravings
- Decreased metabolism and energy expenditure
- Hormonal changes
- Psychological cravings and the return of old eating habits
Reasons to Stop Taking a Weight Loss Drug
These medications are very effective! So why do people stop taking them? Well, for a number of reasons.
Allergic Reactions
Some people may experience allergic responses, including skin rashes, swelling, or difficulty breathing. This would mean they would have to stop the medication immediately.
Side Effects Are Too Much
Common side effects of GLP-1 medications include nausea, vomiting, diarrhea, and constipation. In some cases, these side effects can be too severe to tolerate.
Financial Strains
Many GLP-1 medications are expensive, and insurance companies may not always cover them for weight loss purposes. Patients may be forced to stop due to financial constraints.
Supply and Demand
There have been shortages of medications like Wegovy and Ozempic. This makes it hard for some people to continue their treatment because pharmacies may be unable to fill their prescription.
How to Avoid Regaining Weight After Stopping a Weight Loss Drug
Stopping GLP-1 medications can lead to gaining the weight back, but there are steps you can take to help keep your progress!
Maintaining a Healthy Diet
Having a balanced diet rich in lean proteins, healthy fats, and fiber can help regulate hunger hormones. Try to avoid processed foods, refined sugars, and excessive carbohydrates. These two things together can minimize rapid weight gain.
Incorporating Exercise Into Your Daily Routine
Studies have shown that physical activity is one of the most effective ways to keep weight off. Combining strength training and cardiovascular exercise can help with your metabolism and prevent muscle loss.
Identifying Triggering Events That Lead to Overeating
Many people struggle with emotional eating or unhealthy eating patterns! Recognizing stressors and developing coping strategies can help. These can be tools like mindfulness, therapy, or structured meal planning.
Many people that stop a GLP-1 medication often gain a lot of the weight back. While some people have to stop these medications because of side effects or cost, having a healthy diet and active lifestyle, alongside addressing psychological eating triggers can help with long-term weight management. Hopefully this article helped!
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