
Estimated reading time: 6 minutes
Trying to lose weight can feel like a frustrating, endless cycle. You try different diets, exercise routines, lifestyle changes and maybe you see some progress, but it does not last. With the rise in popularity of GLP-1 medications, you might be wondering if trying out one of these drugs is the next step. Before jumping in, it is important to think carefully about your options, your goals, and your health. Here, PatientsLikeMe will walk through what these medications are, how they work, and the key questions to ask yourself and your doctor before getting started.

Why People Consider Meds for Weight Loss
When lifestyle changes alone don't feel like enough
Many people try to lose weight through diet and exercise. But for some, those changes alone do not lead to lasting results. Weight loss can be complicated and is influenced by things like your metabolism, hormones, mental health, and chronic conditions. In cases like these, your doctor might recommend trying a weight loss medication. These medications are not magic, but they can help you when they are combined with healthy habits.
What these medications are designed to do
There are a few FDA-approved weight loss drugs. The newer medications, like GLP-1 receptor agonists, have shown some dramatic results, helping people lose 10% to 20% of their weight. Originally developed to treat type 2 diabetes, these drugs work by mimicking hormones that help regulate appetite and digestion.
Why Do Weight Loss Medications Work?
What to expect in terms of results
GLP-1 medications help you feel fuller, longer. They slow down how quickly food moves through your stomach, which means you might eat less without feeling hungry. They also help regulate blood sugar levels, which can reduce cravings and keep your energy steady. But results vary person to person. Some people lose a significant amount of weight, others less. These medications work best when paired with a plan for healthy eating and activity.
Questions to Ask Yourself Before You Begin
What are my personal goals and how will I measure progress?
Not everyone with extra weight or type 2 diabetes needs to take a GLP-1 medication! These drugs are prescribed when:
- You are unable to tolerate other treatments like metformin
- You are not meeting your health goals with lifestyle changes alone
- You have related conditions like heart disease or kidney disease
People who are pregnant, have certain GI issues, or have a history of thyroid cancer may not be good candidates. It is important to work closely with your doctor to weigh the benefits and risks.
Am I ready for the emotional and physical shifts that might come with this?
Weight loss can bring emotional highs and lows. On one hand, it can boost your confidence and energy. On the other, people often struggle with body image, how others treat them differently, or what to say when asked how they lost weight. Some people also feel guilt for needing medication or worry they are "cheating." Obesity and overweight are complex, biological conditions. Taking medication is not a shortcut! It is a medical treatment, just like insulin or blood pressure meds. Talking to a therapist can help you prepare for the changes.
Do I understand how this fits into my long-term health plans?
GLP-1 medications are just one part of your health puzzle. You also need to consider how it fits with other goals. These could be managing diabetes, lowering your blood pressure or cholesterol, or feeling stronger and more mobile. You also need to think about how you will keep the weight off over time. Will you stay on the medication long-term? Will you change your eating and activity habits? These are important conversations to have early on.
Questions to Ask Your Healthcare Provider
When you meet with your doctor, ask:
- Do you think I’m a good candidate for a GLP-1 based on my health history?
- Which medication do you recommend and why?
- Is it a pill or injection? How often will I take it?
- What kind of results should I expect?
- How long will I stay on this medication?
- What happens when I stop taking it?
- How will we monitor progress and side effects?
Other Things to Consider Before Starting Medications
Cost, coverage, and how long you may be on it
GLP-1 drugs can be expensive. The coverage you get depends on your insurance plan and diagnosis. Some insurers only cover them if you have type 2 diabetes. Others may limit how long they will cover the medication. Ask about co-pays, pharmacy options, and whether there are patient assistance programs.
Importance of maintaining movement, sleep, and nutrition
Weight loss medications are not a replacement for lifestyle changes. Regular movement, better sleep, and good nutrition all help support your health while you are losing weight. Exercise helps keep weight off long-term and protects muscle and bone. Sleep plays a huge role in moderating metabolism and hunger. Nutrition still matters. Fuel your body with balanced meals to avoid nutrient gaps.
The power of mental health support
Weight and self-image often go hand in hand. If emotional eating, past trauma, or depression are part of your story, a therapist can help. Alma is a great resource for finding in-network mental health care quickly. With over 24,000 providers and coverage from major insurers like Aetna, Cigna, and UnitedHealthcare, Alma can match you with a therapist who fits your needs. Click the link below to try!

GLP-1 medications can be a powerful tool in your weight-loss journey, but they are not a one-size-fits-all solution. Asking the right questions now can help you decide if they’re the right step for you. Think about your goals. Be honest about your needs and challenges. Talk openly with your doctor. And don’t be afraid to seek mental health support along the way.
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