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Managing chronic kidney disease (CKD) and diabetes together can be challenging, but tracking key health indicators can help make it easier. One of the most important tools for monitoring diabetes is the A1C test, which gives a snapshot of your average blood sugar levels over the past two to three months. While it's commonly used to manage diabetes, the A1C test also plays a critical role for kidney patients, especially those dealing with diabetic kidney disease.
In this article, we'll dive into what the A1C test is, its relevance for people with chronic kidney disease, and what to do if your A1C level is high. Additionally, we’ll explore how chronic kidney disease can affect A1C readings and how it impacts your health.

What is the A1C Test?
The A1C test, also known as the glycated hemoglobin test, measures the percentage of hemoglobin in your blood that is coated with sugar (glucose). The higher the blood sugar levels over time, the higher the percentage of glycated hemoglobin. This test is a critical tool for diabetes management, helping doctors evaluate how well a person’s blood sugar levels have been controlled over the last 2-3 months.
For individuals with chronic conditions like diabetes, managing blood sugar is vital to avoid complications, including kidney damage. The A1C test offers a reliable long-term view of blood sugar control, providing more insight than daily blood sugar measurements alone.
Use of the A1C Test in Kidney Patients
For those with chronic kidney disease, especially diabetic nephropathy, the A1C test plays an essential role in managing both conditions. Kidney disease can sometimes make it more difficult to interpret A1C results because reduced kidney function can affect the lifespan of red blood cells, potentially leading to falsely low A1C readings. That said, regular A1C monitoring is still crucial for assessing overall glucose control and adjusting diabetes treatment plans accordingly.
In cases of advanced kidney disease, doctors may also use alternative methods, such as fructosamine tests, a blood test that measures the amount of glycated proteins in the blood to track blood glucose control. That being said, A1C remains the gold standard for most patients, providing a consistent and reliable measure of blood sugar trends.
What to Do If Your A1C Level Is High
If your A1C level is higher than recommended (typically above 6.5% for most individuals with diabetes), it indicates that your blood sugar levels have been elevated over the past few months. For people with chronic kidney disease, high A1C levels can increase the risk of kidney damage and other complications.
Here are a few steps to consider if your A1C levels are high:
- Consult your healthcare provider: If your A1C is elevated, it’s essential to discuss your results with your doctor. They may suggest changes to your medication regimen, diet, or exercise plan.
- Review your diabetes management: Make sure you’re following the prescribed treatment plan for your diabetes. Sometimes, insulin doses or oral medications need to be adjusted.
- Diet and lifestyle changes: Reducing carbohydrate intake, maintaining a balanced diet, and engaging in regular physical activity can help lower blood sugar levels.
- Monitor kidney function: For individuals with CKD, regular kidney function tests, such as serum creatinine, a blood test that measures the level of creatinine in the blood, and GFR (glomerular filtration rate), are also critical to track.
How Does Chronic Kidney Disease Affect A1C in People with Diabetes?

Chronic kidney disease (CKD) can affect the accuracy of the A1C test in individuals with diabetes. As kidney function declines, the kidneys become less efficient at removing waste products from the body, including excess glucose. This can lead to altered blood sugar control, and in some cases, misinterpreted A1C readings.
There are a few reasons why kidney disease might impact A1C:
- Altered red blood cell lifespan: Kidney dysfunction can shorten the lifespan of red blood cells, leading to lower A1C readings than expected.
- Anemia: Many people with CKD also develop anemia, which can distort A1C results.
- Uremia: In severe kidney disease, the buildup of waste products, known as uremia, may interfere with the A1C test.
Doctors might use other tests or adjust your treatment if they think the A1C isn’t giving the full picture of your blood sugar control, especially for kidney patients.
The A1C test is important for managing diabetes, and it’s also crucial for people with kidney disease, particularly those with diabetic nephropathy. While it’s great at showing your average blood sugar over time, both diabetes and kidney disease can make interpreting it trickier. If your A1C levels are high, it’s a good idea to talk with your doctor about tweaking your treatment plan and looking into lifestyle changes.
By staying in close touch with your doctor and taking a well-rounded approach to managing both your blood sugar and kidney health, you can help reduce complications and improve your overall well-being.
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