
Estimated reading time: 6 minutes
Missing a period can be concerning when it turns out you are not pregnant. Whether you are actively trying to conceive or actively trying not to, an irregular cycle can be stressful and worrying. While the average person experiences around 500 menstrual cycles in their lifetime, various factors can disrupt this natural rhythm.
Multiple factors can impact your menstrual cycle from stress to underlying health conditions you should pay attention to. Understanding these causes is crucial for maintaining reproductive health and knowing when to consult a healthcare provider.
Understanding Paused Periods
When menstruation stops unexpectedly, doctors refer to this as amenorrhea – the medical term for the absence of menstrual periods. There are two types:
- Primary amenorrhea: Never getting your first period by age 15
- Secondary amenorrhea: Stopping periods for 3+ months after having regular cycles

Common causes can include:
- Breastfeeding
- Hormonal birth control
- Extreme weight changes
- High-stress levels
- Excessive exercise
- Medical conditions like PCOS or thyroid disorders
What Does a Long Pause in Periods Mean If You're Not Pregnant?
While amenorrhea isn't a disease itself, it often signals an underlying health issue that requires attention. Understanding the root cause is crucial, as prolonged irregular cycles can lead to early-onset menopause and other health complications.
I started to have missed periods and was concerned about this change in pattern, and my doctor told me that if this happens more than once in 12 months, then they start to investigate the cause, and thankfully, I did because it turns out I have PCOS.
It is always a good idea to discuss any changes in menstruation and length of cycles with your doctor, and I do this myself, for reassurance that everything is normal. There are SO many things that impact our cycles, so any fluctuations from the 'norm' should be discussed with your doctor and noted."
PatientsLikeMe Members since 2013
Hormone Imbalances
Hormonal disruptions can significantly impact menstrual cycles. Conditions like thyroid disorders and polycystic ovary syndrome (PCOS) can cause irregular or missed periods due to their effect on reproductive hormones. These imbalances may also cause additional symptoms like weight changes, skin issues, and unusual hair growth.
Stress
Chronic stress can wreak havoc on menstrual cycles by elevating cortisol levels, which affects the hypothalamus—the brain region controlling menstruation. This can lead to hypothalamic amenorrhea, where periods stop completely due to stress-induced hormonal changes.
60% of PatientsLikeMe members with missed periods report serve to moderate stress in their day-to-day.
Eating Disorders
Nutritional deficiencies from eating disorders can halt menstruation. Without proper nutrients, the body cannot produce the hormones necessary for regular cycles. Both severe caloric restriction and malnutrition can cause amenorrhea.
Excessive Exercise
Intense physical training can disrupt menstrual cycles, especially when combined with low body weight or inadequate caloric intake. Athletes and dancers often experience exercise-induced amenorrhea due to the physical stress on their bodies.

Primary Ovarian Insufficiency (POI)
POI is a condition where ovaries stop functioning normally before age 40. This condition:
- Affects 1% of women under 40
- Causes irregular or stopped periods
- Reduces estrogen production
- May impact fertility
- Can have genetic or autoimmune causes
Symptoms Include
- Hot flashes
- Night sweats
- Vaginal dryness
- Mood changes
- Difficulty concentrating
- Decreased sex drive

POI: Diagnosis, Fertility & Genetics
Diagnosis Process:
Healthcare providers diagnose POI through blood tests to check hormone levels, genetic testing, medical history review, and physical examination. They'll also evaluate your menstrual history for irregular patterns.
Fertility Impact:
While POI significantly reduces fertility, pregnancy isn't impossible. About 5-10% of women with POI may conceive naturally. Some retain intermittent ovarian function and may still have eggs, though their quantity and quality are typically reduced. Fertility treatments and egg donation are options for those wanting to become pregnant.
Genetic Factors:
POI can have a hereditary component, with 10-20% of cases showing a family history. Genetic testing can help identify inherited factors that may have contributed to the condition.
Amenorrhea and POI Connection
Both amenorrhea and POI involve interrupted menstruation, but they're distinct conditions:
- Amenorrhea is a symptom that can have many causes
- POI is a specific condition causing amenorrhea
- POI requires hormone replacement therapy
- 79% of PatientsLikeMe Members who are taking HRT to treat POI rate it highly effective in managing irregular periods
- Amenorrhea treatment depends on the underlying cause

How Is This Missed Period Different from Perimenopause?
While both conditions involve hormonal changes, POI differs from perimenopause in timing and cause. Perimenopause typically occurs between 45-55 years and is a natural transition. POI, however, happens prematurely and may result from genetic factors, autoimmune conditions, or unknown causes.

Treatment Options for Missed Periods and POI
Treatment approaches vary depending on the underlying cause:
- Hormone replacement therapy for POI and hormonal imbalances
- Stress management techniques and counseling
- 47% of PatientsLikeMe with amenorrhea report that meditation is highly effective in managing their stress symptoms
- Nutritional support and weight management programs
- Modified exercise routines when excessive training is the cause
- Medication adjustments if birth control or other medications are factors
Next Steps for Managing Irregular Periods
While missed periods can be alarming, understanding the various causes helps identify appropriate treatment options. Regular medical check-ups and prompt attention to menstrual irregularities are essential for maintaining reproductive health.
PatientsLikeMe can help. You can join a community of women sharing similar experiences with irregular periods and POI. Our platform enables you to track your symptoms, menstrual cycles, and treatment responses while connecting with others who understand your journey firsthand.
Members share their personal stories, treatment experiences, and coping strategies through detailed testimonials. From lifestyle modifications to treatment decisions, you'll find practical advice and motivation from women who've walked this path before you.
