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Ozempic is a drug also known as semaglutide. This drug has come on the scene recently and is helping people to lose weight, manage their diabetes and obesity. Changing countless lives, the drug has taken off as immensely popular and is considered highly effective. But there are some side effects of Ozempic that should be noted including affecting a person’s menstrual cycle or period, albeit indirectly.

What is Semaglutide?
Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. “These drugs mimic the effects of GLP-1, which regulates blood sugar levels by stimulating insulin secretion and reducing the production of glucagon, a hormone that increases blood sugar levels.” It has been shown to be effective in improving blood sugar control, promoting weight loss, and reducing cardiovascular risks in people with type 2 diabetes.
Ozempic and Menstruation
Ozempic specifically affects insulin and glucagon levels to regulate blood sugar. According to Genesis Lifestyle Medicine, “It does not directly target or influence the production or activity of estrogen, progesterone, or other hormones involved in the menstrual cycle. Therefore, Semaglutide doesn’t directly affect the hormonal levels associated with the menstrual cycle, so it doesn’t directly affect the menstrual cycle.”
As a result of causing extreme weight loss, your period may be impacted by ozempic anyway.
Ozempic can cause:
- Decreased food intake.
- Prolonged feelings of fullness
- Enhanced glucose uptake into cells

Weight loss, at any point, can result in hormonal fluctuations or changes. Fat cells produce hormones which regulate metabolism and appetites. These hormones are impacted by extreme changes in weight. When these hormones are impacted, hormones such as estrogen and progesterone (which directly impact your menstruation) can also be impacted. The use of ozempic and extreme weight loss may cause:
- Irregular Periods
- Heavier or Lighter Bleeding
- Missed Periods
- Amenorrhea: The absence of menstruation, due to hormonal imbalances that suppress ovulation.
- Other Symptoms such as cramping, bloating, or mood changes. These symptoms can vary in intensity and duration.
If you experience significant changes in your menstrual cycle while taking Semaglutide, please consult your healthcare provider. They can help determine whether these changes are related to the medication or if other underlying factors may be the cause. Seek help and support as you navigate any major body changes or introduce new medications to your regimen for your mental and physical safety.
