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Living with chronic kidney disease (CKD) comes with a number of challenges! One of the most significant concerns is managing hypertension, or high blood pressure. In the United States alone, more than 122 million people have high blood pressure. That is roughly half of all Americans ages 20 and up. For those who are 65 and up, that rate increased to over 75% of all adults. So why should you focus on your blood pressure? In this guide, PatientsLikeMe will explore why hypertension is crucial in CKD. We will cover the common medications used to treat it and how you can effectively manage this condition.
Why is it Important to Manage Hypertension?
Hypertension is a common complication of CKD and plays a crucial role in the progression of kidney damage. When blood pressure is consistently high, it puts extra strain on the kidneys. This in turn leads to further deterioration of kidney function over time. Higher blood pressure means a weaker kidney, which worsens symptoms and overall health. Managing hypertension is important for preserving kidney health. It can also slow the progression of CKD.
In addition to its impact on kidney function, uncontrolled hypertension increases the risk of other complications. These include things such as heart disease, stroke, and damage to blood vessels throughout the body. If you can manage your blood pressure, your whole body will thank you. Heart failure is still the leading cause of death nationwide, and worth paying attention to at any age.
Common Medications
There are several options for treating hypertension if you have CKD. Certain medications work by lowering blood pressure and reducing the strain on the kidneys and other organs. Here are the most common classes of antihypertensive medications.
- Angiotensin-Converting Enzyme (ACE) Inhibitors: ACE inhibitors help relax blood vessels, making it easier for blood to flow and reducing blood pressure. Examples include lisinopril, enalapril, and ramipril.
- Angiotensin II Receptor Blockers (ARBs): ARBs block the action of angiotensin II. This is a hormone that narrows blood vessels and raises blood pressure. By blocking this hormone, ARBs help lower blood pressure. Examples include losartan, valsartan, and irbesartan.
- Calcium Channel Blockers: Calcium channel blockers relax blood vessels by preventing calcium from entering cells in the heart and blood vessel walls. This relaxation helps lower blood pressure. Examples include amlodipine, diltiazem, and verapamil.
- Diuretics: Diuretics, also known as water pills, help the kidneys remove excess sodium and water from the body. In turn this reduces the volume of blood and lowers blood pressure. Examples include hydrochlorothiazide, furosemide, and spironolactone.
- Beta-Blockers: Beta-blockers reduce the heart rate and the force of contraction, which helps lower blood pressure. Examples include metoprolol, carvedilol, and atenolol.

Medication Side Effects
While antihypertensive medications are generally safe and effective, they can sometimes cause side effects. It is important to be aware of potential side effects and talk to your healthcare provider if you experience any. Here are the most common side effects of antihypertensive medications.
- Dizziness or lightheadedness
- Fatigue or weakness
- Dry cough (associated with ACE inhibitors)
- Leg swelling (edema)
- Headache
- Nausea or upset stomach
- Erectile dysfunction (in men)
- Changes in blood potassium levels (associated with diuretics)
- Rash or allergic reaction
Working to Manage Hypertension
A balanced diet low in sodium, saturated fats, and cholesterol can help lower blood pressure and reduce strain on the kidneys. Focus on fresh fruits and vegetables, whole grains, lean proteins, and low-fat dairy products. Losing excess weight can also help lower blood pressure and improve kidney function. Aim for a gradual, sustainable weight loss through a combination of healthy eating and regular physical activity.
Too much alcohol and caffeine can raise blood pressure. Limit alcohol to moderate levels and avoid excessive caffeine intake from coffee, tea, and energy drinks. Regular physical activity can help lower blood pressure, improve cardiovascular health, and manage stress. Aim for at least 30 minutes of moderate-intensity exercise most days of the week, such as walking, swimming, or cycling. If your healthcare provider has prescribed medications to lower your blood pressure, take them exactly as directed. Be sure to follow up with your provider regularly to monitor your blood pressure and adjust your treatment plan as needed.

If you have CKD, managing hypertension is an important part of your care. By keeping a healthy lifestyle and taking medications as prescribed, you will see results! You can lower your blood pressure, protect your kidneys, and reduce the risk of complications associated with CKD and hypertension. Remember to talk to your doctor about any concerns or questions you may have.
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