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Researchers in Canada looked at how two medications, low-dose methotrexate and hydroxychloroquine, affected older adults with Chronic Kidney Disease (CKD). They found that those who took low-dose methotrexate had a higher chance of having serious problems. They also had a higher probability of needing a hospital visit compared to those who took hydroxychloroquine. 2,309 individuals started methotrexate with a matched hydroxychloroquine group. Those on methotrexate faced a significantly higher risk of serious adverse events requiring hospitalization at 90 days (3.55% vs. 1.73%).
Most of the people in the study had a condition called rheumatoid arthritis. The serious problems happened about 7 weeks after starting the medications. When they looked at people with lower kidney function, those taking low-dose methotrexate had an even higher chance of health issues.
The study suggests that if people with kidney problems are going to take low-dose methotrexate, they should be checked regularly. Providers should monitor for different symptoms like blood issues, infections, and lung or liver problems. The study has some limitations. It was unable able to see if people took their medications properly, and it only looked at older adults with kidney problems. It's important to think carefully about the risks and benefits when choosing medications.
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